PERQUE
ACTIVATED B-12 GUARD™
SUBLINGUAL LOZENGE:
AN ORAL “INJECTION” FOR ENERGY AND DETOXIFICATION
PERQUE Activated B-12 Guard is in lozenge form for maximum uptake and optimal delivery to the brain.

Studies on PERQUE Activated B-12 Guard lozenge formulation show nearly the same B-12 uptake as from injection.
Patients notice that they feel better more quickly.*

Vitamin B-12 in our food supply is estimated to be 78% less than in the 1960s. Diet alone is hard pressed to provide the necessary levels of this important nutrient. In addition, stress and reduced hydrochloric acid (HCl) and intrinsic factor production in the stomach impair absorption. The most commonly used forms of B-12 require activation in the body, making uptake quite low—rarely more than 50%.*

PERQUE delivers vitamin B-12 in its superior, activated hydroxocobalamin form.

Although it is more expensive and difficult to obtain, hydroxocobalamin lasts longer and raises B-12 blood concentrations higher than other forms. For this reason, it is the only form PERQUE uses. Hydroxocobalamin requires no intrinsic factor and is taken up directly by mucous membranes regardless of digestive competence.* Hydroxocobalamin is easily converted to active but short-lived methylcobalamin and adenosylcobalamin as needed in the body. Hydroxocobalamin, the parent to other B-12 forms, provides better, long-lived B-12 action in the body.

ACTIVATED B-12 GUARD
FOR SAMe!
Optimal absorption of vitamin B-12 is essential to keep SAMe (S-adenosyl methionine) in its beneficial form. SAMe is critical for the manufacture of brain chemicals and for detoxification.*

ACTIVATED B-12 GUARD
PROMOTES HEART HEALTH
The correlation between homocysteine and vitamin B-12 is significant. Nearly 57% of men with elevated homocysteine have low levels of B-12. Signs of deficiency may take as long as six or
more years to manifest clinically. Meanwhile, as homocysteine levels climb, cardiovascular risk rises. B-12 Guard, taken with the synergistic nutrients B-6 and folic acid (both found in PERQUE2 Life Guard), delivers maximum action for keeping homocysteine levels low.*

B-12 AND FOLIC ACID
The connection between vitamin B-12 and folic acid is also critical. Vitamin
B-12 reactivates folic acid. If an individual has low levels of vitamin B-12, severe folic
acid deficiency may develop. Similarly, a B-12-deficient individual taking only folic
acid can make the B-12 deficiency worse. Chronically low levels of B-12 result in
megaloblastic (B-12) anemia. The solution: Always take both B-12 and folate, which
can be found in PERQUE2 Life Guard and in PERQUE Hematin Anemia Guard.*

ACTIVATED B-12 GUARD
FIGHTS FATIGUE
Hectic lifestyles, stress, and increasing levels of toxins in the environment can lead to exhaustion. Individuals suffering from fatigue can benefit from B-12 supplementation. B-12 stimulates the body’s utilization of proteins, fats, and carbohydrates, which in
turn can increase energy. Research shows that 2-20 mg. (2,000 - 20,000 mcg) daily is
required for optimal benefit. Each B-12 Guard lozenge delivers 2,000 mcg of B-12.*

MORE ABOUT HOMOCYSTEINE
The importance of maintaining normal homocysteine levels cannot be overemphasized. Your heart health depends on it. Clearly, the scientific evidence indicates that nutrient deficiency is a factor in elevated homocysteine levels. However, in a recent study, researchers discovered that in many patients, even when serum levels of vitamins appear to be normal, homocysteine concentrations were still too high.* Elevated homocysteine levels are implicated in much more than heart disease. In a study of women with both chronic fatigue and fibromyalgia, researchers discovered that all of the patients had high levels of homocysteine in their cerebrospinal fluid. They also noted a significant correlation between high homocysteine levels and fatigue. The study emphasized the importance of the relationship between B-12 and homocysteine, and showed that B-12 deficiency was a contributing factor. By decreasing levels of homocysteine in the central nervous system, B-12 can help prevent and treat fatigue.*